Aerobic Training and Crocin Consumption Improve Doxorubicin Damage to Spermatogenesis Process and Luteinizing Hormone Receptor Expression of Male Wistar Rats

Background: Many men in the world are infertile at reproductive age. One of causes male infertility is side effects chemotherapy drugs. Doxorubicin (DOX) a tetracycline used that has been shown to have adverse on testicular tissue. Objectives: The simultaneous effect high-intensity aerobic exercise and crocin (Cr) consumption doxorubicin-induced tissue not studied. Therefore, aim this study was investigate interaction between Cr spermatogenesis expression lutein hormone receptor (LHR) rats injected with doxorubicin. Methods: Thirty Wistar were randomly divided into five groups (n = 6), including (1) healthy control, (2) doxorubicin, (3) doxorubicin + 10 mg/kg body weight (kg.bw) Cr, (4) high intensity interval training (HIIT) (5) mg/kg.bw Cr. Rats 3 5 received daily specific doses orally, 4 performed (2 - 8 rep × 2 min 80 110% Vo2max) days/w. Also, two peritoneally seven times throughout study. Expression LHR measured by immunohistochemistry (IHC) hematoxylin eosin (H&E), respectively. Results: Data analysis showed significant decrement group compared control (P ≤ 0.0001). HIIT caused most increase 0.03). higher than 0.05). Conclusions: To prevent harmful recommended. positive significantly consumption.